Nope, the pin out on the games is different. CD games are region free though. This is why it is better to get a PC Engine over a Turbografx: there's only a few Turbografx games that you'll miss out on, that are actually worth is (Neutopia & Dragon's Curse come to mind, which are both translated rpg's on Hu Cards, or Turbo Chips as they are called in the US, and Dragon's Curse is actually Wonder Boy 3 on the Master System so...), the other translated rpg's are all on CD format (YS 1, 2, & 3, Exile, Dynastic Hero,...) so those can be played perfectly on a PC Engine. Another reason to get a PC Engine instead of a Turbofrafx, is its vastly superior library: there are literally 500 more games on the PC Engine and most of those are perfectly playable for non Japanese speakers, it has a ton of shooters, platformers, action adventure games, puzzlers, etc...
We are SEGA generation.my collectionvids
310 JAP games to go