OPTIONAL: For the ROM list to load quicker (by not reading each ROMs header for the game's title) you can use a ROM list creator. ROMS.LST Maker v1.2 by kRYPT_ is recommended.
OPTIONAL: If you don't want DreamSNES to scan a certain directory you can stick a file named NO_ROMS.HERE in it. This will prevent DreamSNES from scanning it for ROMs.